Three finished site directions — switch to compare.

Mark Grier

Selected writing

Publications and patents

A sample of peer-reviewed work and patent filings. Additional patents, publications, and presentations are available on request.

Papers

  1. Gilleran JA et al., including Grier MC. Structure–Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. J. Med. Chem. 2024, 67(5):3467–3503.
  2. Mottis A et al., including Grier MC. Tetracycline-induced mitohormesis mediates disease tolerance against influenza. J. Clin. Invest. 2022, 132(17):e151540.
  3. Bryan EJ, Sagong HY, Parhi AK, Grier MC, Roberge JY, LaVoie EJ, Pilch DS. TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens. Antibiotics 2022, 11(5):693.
  4. Mai N et al., including Grier M. Effects of 9-t-butyl doxycycline on the innate immune response to CNS ischemia-reperfusion injury. Exp. Mol. Pathol. 2021, 118:104601.
  5. Grier MC et al. N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability. Bioorg. Med. Chem. Lett. 2010, 20(11):3380–3383.
  6. Kim O, Garrity-Ryan LK, Grier MC et al. N-hydroxybenzimidazoles as Novel Inhibitors of a Transcription Factor LcrF in Yersinia: Potent Anti-Virulence Agents. J. Med. Chem. 2009, 52(18):5626–5634.
  7. Nelson ML, Grier MC, Barbaro SE, Ismail MY. Polyfunctional antibiotics affecting bacterial membrane dynamics. Anti-Infective Agents in Medicinal Chemistry 2009, 8(1):3.
  8. Bowser TE, Bartlett VJ, Grier MC et al. Novel anti-infection agents: Small-molecule inhibitors of bacterial transcription factors. Bioorg. Med. Chem. Lett. 2007, 17(20):5652–5655.

Patents

  1. Alekshun MK et al., including Grier M. Preparation of substituted benzoimidazole compounds as modulators of transcription factor for the treatment of infection diseases. PCT Int. Appl. WO 2010124097 A2 (2010).
  2. Seyedi F, Warchol T, Grier M. Methods for synthesizing substituted tetracycline compounds. PCT Int. Appl. WO 2009009042 A1 (2009).
  3. Abato P et al., including Grier M. Substituted tetracycline compounds for treatment of bacterial infections and neoplasms. PCT Int. Appl. WO 2008079339 A2 (2008).
  4. Abato P et al., including Grier M. Preparation of 10-substituted tetracycline compounds as antibiotics. PCT Int. Appl. WO 2007014154 A2 (2007).
  5. Amoo V et al., including Grier, Mark. Prodrugs of 9-aminomethyltetracycline compounds. U.S. Pat. Appl. Publ. US 2006287283 A1 (2006).
  6. Abato P et al., including Grier M. Preparation of substituted tetracycline compounds for the treatment of bacterial infections and neoplasms. PCT Int. Appl. WO 2006047756 A2 (2006).